BRAF V600 Mutation Detection Clinical Significance: BRAF V600 mutation analysis is useful in determining patient eligibility for targeted EGFR inhibitor therapy for metastatic colorectal carcinoma and for Lynch syndrome reflex testing (in colorectal carcinomas).…
Colorectal Carcinoma Molecular Analysis Clinical Significance: Recently established guidelines from the American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP) and/or the American Society…
HER2 Gene Amplification Clinical Significance: The American Society of Clinical Oncologists (ASCO), ASCP, CAP, AMP, and National Comprehensive Cancer Network (NCCN) recommend HER2 gene amplification status determination on colorectal cancer patients inappropriate…
KRAS Mutation Detection Clinical Significance: The American Society of Clinical Oncologists (ASCO), ASCP, CAP, AMP, and National Comprehensive Cancer Network (NCCN) recommend routine testing for RAS mutation at diagnosis of stage IV disease and all colorectal…
Microsatellite Instability (MSI) Analysis Clinical Significance: Recently established guidelines from the American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP) and/or the American…
NRAS Mutation Detection Clinical Significance: The American Society of Clinical Oncologists (ASCO), ASCP, CAP, AMP, and National Comprehensive Cancer Network (NCCN) recommend routine testing for RAS mutation at diagnosis of stage IV disease and all colorectal…
