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Dahl Chase Folders

FISH for ALK Gene Rearrangements

Reference Number: AA-00433

SECTION EIGHT

Dahl-Chase Diagnostic Services

MOLECULAR PATHOLOGY TESTING

FISH FOR ALK GENE REARRANGEMENTS

 

Clinical Significance:

 

ALK (2p23) rearrangements can be found in 2-7% of non small-cell lung carcinomas (NSCLC),  more commonly in adenocarcinomas of never or light smokers, whose tumors lack EGFR and KRAS mutations.  ALK rearrangements, due to fusion with various other genes (such as ALK-EML4) render the tumors sensitive to ALK inhibitors such as critozinib (while resistant to EGFR tyrosine kinase inhibitor therapies)

 

 

Specimen Requirements and Collection:

Formalin fixed tissue containing a sufficient amount of tumor (generally at least several mm of tumor tissue submitted in the tissue block). 

 

Forms:

Molecular Pathology requisition form

 

Transport:

Send paraffin block containing tumor at room temperature

 

Reference Range:

ALK gene rearrangement present = positive result

ALK gene rearrangement not detected = negative result

 

 

CPT codes:

88377

 

 

 

Test reported:

Results are reported within 7-10 days