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Dahl Chase Folders

Epidermal Growth Factor Receptor (EGFR) Mutation Analysis

Reference Number: AA-00432


SECTION EIGHT

Dahl-Chase Diagnostic Services

MOLECULAR PATHOLOGY TESTING

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) MUTATION ANALYSIS

 

Clinical Significance:

 

This test is used to detect specific mutations of the EGFR gene (exons 18-19, 20 and 21), including point mutations, deletions and insertions reported to occur in characteristic locations throughout the above exons.  This testing allows identifying patients who are most likely to respond to targeted lung cancer therapy, including tyrosine kinase inhibitors erlotinib and gefitinib.  The mutations occur in 10%-50% of patients (lower in Caucasians, higher in Asian patients).

 

 

Specimen Requirements and Collection:

Formalin fixed tissue containing a sufficient amount of tumor (generally at least several mm of tumor tissue submitted in the tissue block). 

 

Forms:

Molecular Pathology requisition form

 

Transport:

Send paraffin block containing tumor at room temperature

 

Reference Range:

EGFR mutation present = positive result

EGFR mutation not detected = negative result

 

 

CPT codes:

88381, 81235, G0452

 

 

 

Test reported:

Results are reported within 7-10 days